The Spanish word despectivo means "contemptuous," "derogative", or "pejorative." You can use this word in expressions such as No me hables con ese tono despectivo (Don't talk to me using that pejorative tone) or Él es un tipo muy despectivo (He's a very derogative guy).
The word despectivo is also used to describe adjetives and nouns that express disapproval or disdain. You can form these pejorative adjectives and nouns by adding suffixes to root words. The use of prefixes to form pejoratives is not very common, although the etymology of words such as imbécil (imbecile) shows that sometimes prefixes can be used to form words with a pejorative meaning as well. For example:
A veces soy un poco despistada.
Sometimes I'm a bit airheaded.
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The word despistada is formed with the Spanish prefix de- (meaning a lack or absence of something) and the word pista (clue); hence another possible translation for this word is "clueless."
Suffixes are, however, much more commonly used to form augmentative, diminutive, and pejorative words in Spanish (actually, in most languages). For example, the suffix -acho/-acha is used to form the pejorative populacho (pleb, mob). Another common pejorative suffix is -ucho/-ucha. You can add it to the root of the word casa (house) to form casucha (hovel, shack), to the word pueblo (town) to form the word pueblucho (hick town), and to practically any other Spanish noun!
The pejorative suffix -astro/-astra can be used to form words such as camastro (rickety old bed). It's actually in the origin of words such as madrastra (stepmother), hijastro (stepson), etc.:
Y mi padrastro, porque mi padre murió, se llama Luis Manuel.
And my stepfather, because my father died, is named Luis Manuel.
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It's also very common to use augmentative or diminutive suffixes as pejorative ones, due to the fact that the excess or lack of something is usually perceived as a negative thing. For example, the Spanish augmentative suffix -ón/-ona is commonly used to form pejorative words such as gordinflón (fatty), panzón (potbellied), comelón (glutton), llorón (cry baby), and mandón:
La verdad es que Camilo es un poco mandón y un poco raro,
The truth is that Camilo is a bit bossy and a bit strange,
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Some diminutive suffixes can be used pejoratively as well. For example the suffix -illo/-illa is used in words such as trabajillo (insignificant job) or lucecilla (dim light). If you want to learn more about these suffixes, we recommend you watch Raquel's video on the topic: Raquel - Diminutivos y aumentativos.
Thank you for reading!